Hypogonadotropic Hypogonadism Clinical Trial
Official title:
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.
- Assignment: Each study subject will serve as their own control. The order of kisspeptin doses will be randomized within each set/exposure. - Delivery of Interventions: - Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories. Subjects will also wear a gonadotropin releasing hormone (GnRH) pump prior to the inpatient study visit. - On the day of the inpatient study, the subjects will - Undergo q10 min blood sampling for 6 hours, - Receive kisspeptin intravenous (IV) boluses from hour 6 to hour 44 (20 boluses total), - Undergo q10 min blood samplings for another 6 hours, - Receive a single GnRH IV bolus at hour 51. ;
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