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Clinical Trial Summary

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of gonadotropin-releasing hormone (GnRH) and kisspeptin, two other naturally occurring reproductive hormones.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01952782
Study type Interventional
Source Massachusetts General Hospital
Contact Study Coordinator
Phone 617-643-2308
Email MGHKisspeptinResearch@partners.org
Status Recruiting
Phase Phase 1
Start date April 30, 2014
Completion date August 2025

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