Neuropeptides in Human Reproduction

Status Recruiting

Clinical Trial Summary

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of gonadotropin-releasing hormone (GnRH) and kisspeptin, two other naturally occurring reproductive hormones.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01952782
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Study Coordinator
Phone	617-643-2308
Email	MGHKisspeptinResearch@partners.org
Status	Recruiting
Phase	Phase 1
Start date	April 30, 2014
Completion date	August 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01438073` - Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling	Phase 1
Completed	`NCT01403532` - Sequential Therapy for Hypogonadotropic Hypogonadism	Phase 4
Recruiting	`NCT00456274` - Baselines in Reproductive Disorders	N/A
Terminated	`NCT05205837` - A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial	Phase 4
Completed	`NCT02908074` - A 6 Month Safety Extension Study of MBGS205	Phase 2
Completed	`NCT05752591` - Hypothalamic-pituitary Dysfunction in Diabetes
Terminated	`NCT03118479` - Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)	Phase 1
Completed	`NCT02730169` - Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism	Phase 2
Completed	`NCT02110368` - Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions	Phase 3
Recruiting	`NCT01601171` - Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
Completed	`NCT01623570` - Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP	N/A
Terminated	`NCT00328926` - Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L])	Phase 4
Completed	`NCT01438034` - Kisspeptin in the Evaluation of Delayed Puberty	Phase 1
Completed	`NCT04456296` - A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism	Phase 4
Recruiting	`NCT00914823` - Kisspeptin Administration in the Adult	Phase 1
Terminated	`NCT01155518` - Hypogonadism in Young Men With Type 2 Diabetes	Phase 2
Completed	`NCT00697814` - Clomiphene in Males With Prolactinomas and Persistent Hypogonadism	Phase 2
Active, not recruiting	`NCT00351416` - Letrozole Treatment in Normal and GnRH Deficient Women	Phase 2/Phase 3
Recruiting	`NCT05971836` - The Molecular Basis of Inherited Reproductive Disorders
Recruiting	`NCT02705014` - Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome	N/A