Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

Status Completed

Clinical Trial Summary

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Clinical Trial Description

Please contact study staff for a detailed description. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01438073
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Completed
Phase	Phase 1
Start date	September 2011
Completion date	April 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01403532` - Sequential Therapy for Hypogonadotropic Hypogonadism	Phase 4
Recruiting	`NCT00456274` - Baselines in Reproductive Disorders	N/A
Terminated	`NCT05205837` - A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial	Phase 4
Completed	`NCT02908074` - A 6 Month Safety Extension Study of MBGS205	Phase 2
Completed	`NCT05752591` - Hypothalamic-pituitary Dysfunction in Diabetes
Terminated	`NCT03118479` - Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)	Phase 1
Completed	`NCT02730169` - Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism	Phase 2
Completed	`NCT02110368` - Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions	Phase 3
Recruiting	`NCT01601171` - Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
Completed	`NCT01623570` - Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP	N/A
Terminated	`NCT00328926` - Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L])	Phase 4
Completed	`NCT01438034` - Kisspeptin in the Evaluation of Delayed Puberty	Phase 1
Completed	`NCT04456296` - A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism	Phase 4
Recruiting	`NCT00914823` - Kisspeptin Administration in the Adult	Phase 1
Terminated	`NCT01155518` - Hypogonadism in Young Men With Type 2 Diabetes	Phase 2
Completed	`NCT00697814` - Clomiphene in Males With Prolactinomas and Persistent Hypogonadism	Phase 2
Active, not recruiting	`NCT00351416` - Letrozole Treatment in Normal and GnRH Deficient Women	Phase 2/Phase 3
Recruiting	`NCT05971836` - The Molecular Basis of Inherited Reproductive Disorders
Recruiting	`NCT02705014` - Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome	N/A
Recruiting	`NCT04648969` - Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism	Phase 2