Hypogonadism Clinical Trial
NCT number | NCT00004335 |
Other study ID # | 199/11894 |
Secondary ID | UMMC-271 |
Status | Completed |
Phase | N/A |
First received | October 18, 1999 |
Last updated | June 23, 2005 |
Start date | April 1993 |
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone
(GnRH) and sex steroid secretion in normal and hypogonadal children.
II. Examine the acute effects of sex steroids on the sleep-entrained patterns of GnRH
secretion in pubertal children and normal adults, either by stimulation of endogenous
production with pulsatile injection or by intravenous infusion of GnRH.
III. Examine the role of endogenous opioids by means of opioid receptor blockade in the sex
steroid regulation of GnRH secretion in pubertal children and normal adults.
Status | Completed |
Enrollment | 0 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 7 Years to 35 Years |
Eligibility |
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Suspected or proven hypothalamic-pituitary-gonadal dysfunction, i.e.: Significant short stature and possible hypopituitarism Delayed adolescence Precocious puberty Isolated growth hormone deficiency (IGHD)Primary hypogonadism - Women are also studied, including those with the following disorders: Infertility Oligo- or amenorrhea Hirsutism --Patient Characteristics-- - Age: 7 to 16 (18 to 35 for women and volunteers) - Other: No pregnant or nursing women No prisoners Not in neuropsychiatric institute or other facility for mental illness |
Primary Purpose: Screening
Country | Name | City | State |
---|---|---|---|
United States | University of Michigan Health Systems | Ann Arbor | Michigan |
Lead Sponsor | Collaborator |
---|---|
National Center for Research Resources (NCRR) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Michigan |
United States,
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