Hypogonadism, Male Clinical Trial
Official title:
Salivary Testosterone in Men: Diurnal Variation and Post-prandial Responses
The purpose is to evaluate Sal-T against standard biomarkers of male gonadal status based on serum T, calculated free T and BAT. The optimal salivary sampling in terms of fasting and time of day will also be defined. The ultimate aim is to add Sal-T into the Trust's repertoire of tests in investigating suspected hypogonadism in men.
To investigate whether salivary (free) testosterone is subject to similar prandial variations reported for serum total testosterone. Study 1: Assessment of diurnal variation in salivary testosterone adjusted for prandial state in 20 healthy men. Study 2: Measurement of salivary and serum testosterone and related biomarkers before and after a standard 75g oral glucose load in 40 men. ;
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