Mechanisms of Hypoglycemia in Patients Without Diabetes

Hypoglycemia Clinical Trial

Official title: Mechanisms of Hypoglycemia in Patients Without Diabetes

Status Active, not recruiting

Clinical Trial Summary

The goal of this study is to identify physiologic and molecular mechanisms that underlie hypoglycemia in the absence of diabetes (or medications that can cause hypoglycemia) and to investigate potential genetic and microbiome differences which contribute to hypoglycemia. We will test the hypothesis that hypoglycemia in the absence of diabetes is linked to genetic variation or the microbiome, and identify whether additional medical history or diagnoses are enriched in the population of patients with hypoglycemia.

Clinical Trial Description

Although there are several conditions which have been identified that cause, or contribute to hypoglycemia, diagnosis can be challenging, as the physiologic, and molecular mechanisms are incompletely understood. Additionally, treatment options are relatively limited, and often incompletely effective and/or not well tolerated. Investigating the causative factors and mechanisms of hypoglycemia is important therefore in improving our understanding in order to develop new and more effective approaches to treatment.

The current study aims to:

1. more fully characterize clinical history and demographics in patients with diverse forms of hypoglycemia by creating and analyzing a patient database;

2. for a subset of patients, characterize metabolic and hormonal responses to a standard meal;

3. analyze DNA variants in individuals with hypoglycemia;

4. analyze differences in the intestinal microbiome in individuals with hypoglycemia. ;

Related Conditions & MeSH terms

• Hypoglycemia

• NCT number: NCT04428723
• Study type: Observational [Patient Registry]
• Source: Joslin Diabetes Center
• Status: Active, not recruiting
• Start date: August 11, 2020
• Completion date: May 2025