CREON for the Treatment of Post-RYGB Hypoglycemia

Status Terminated

Clinical Trial Summary

Hypoglycemia is an increasingly recognized complication of Roux-en-Y gastric bypass (RYGB) that is poorly understood and difficult to treat. Investigators hypothesize that after RYGB some patients have incomplete carbohydrate absorption in the small intestine which leads to inconsistent glucose levels and hypoglycemia during oral consumption of a meal. Investigators further hypothesize that pancreatic enzyme supplementation with (Creon) during meals and snacks will improve carbohydrate absorption and lead to more stable glucose levels in patients with post-RYGB hypoglycemia.

Clinical Trial Description

Primary Objective: Evaluate the feasibility and safety of Creon in the treatment of post-RYGB hypoglycemia as add-on therapy to a diet higher in protein and lower in carbohydrate. Secondary Objective: Evaluate utility of continuous glucose monitoring (CGM) in monitoring hypoglycemia as an adjunct to standard venous blood testing using a glucometer in post-RYGB hypoglycemia. ;

Study Design

Related Conditions & MeSH terms

Hypoglycemia

Clinical Trial Details

NCT number	NCT02733848
Study type	Interventional
Source	East Carolina University
Contact
Status	Terminated
Phase	Phase 1
Start date	February 2014
Completion date	January 31, 2018

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