Free Fatty Acids: Short Exposure Study

Hypogeusia Clinical Trial

Official title:

Free Fatty Acids: Short Exposure Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01686113
• Other study ID #: 1205012317
• Status: Completed
• Phase: N/A
• First received: September 12, 2012
• Last updated: November 20, 2014
• Start date: May 2012
• Est. completion date: May 2014

Study information

• Verified date: November 2014
• Source: Purdue University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.

Description:

The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste - is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: May 2014
• Est. primary completion date: May 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• good health

• available for multiple testing visits

Exclusion Criteria:

• have participated in a fat taste study in the past 6 months

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Hypogeusia

Intervention

Other:
• NEFA

• Sucrose

Locations

Country	Name	City	State
United States	Purdue University	West Lafayette	Indiana

Sponsors (1)

Lead Sponsor	Collaborator
Purdue University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	NEFA detection threshold		10 days	No
Secondary	Hunger	Visual analog scale assessment of hunger level prior to testing	2 days	No
Secondary	BMI		1 day	No
Secondary	Taste descriptor	Description of NEFA taste by participant, e.g., sour, bitter, etc.	10 days	No