Vitamin D Deficiency Clinical Trial
Official title:
The Impact of Vitamin D Deficiency on Hypocalcaemia Following Total Thyroidectomy
Post-operative hypocalcaemia following total thyroidectomy is a well-known complication and
becoming a major area of research.
Many factors are assumed to increase the incidence of post-thyroidectomy hypocalcaemia, but
the impact of vitamin D deficiency remains uncertain.
Since results so far were inconclusive, the goal in this study is to significantly determine
the relation between those two factors.
This study is the first to deal with this issue through patients who underwent total
thyroidectomy that was performed by the same surgeon and the same surgical technique.
A retrospective evaluation study of patients who underwent total thyroidectomy at the head
and neck unit of the Otorhinolaryngology department at our institution between January 2013
and October 2016.
A total number of 60 patients underwent total thyroidectomy with available vitamin D levels
before surgery, as well as pre and post-operative PTH and calcium levels.
Pre-operative vitamin D and PTH levels were checked within a maximum of one month duration
before surgery.
All patients were operated by the same surgeon -Dr. Galit Avior-, with the same surgical
technique.
The study involves access to the patients files and admission reports. In addition the
investigators would like to be able to call the patients in order to ask them whether
Vitamin D deficiency was corrected or not before their surgery, and If it was corrected then
when exactly.
Background Post-operative hypocalcaemia following total thyroidectomy is a well-known
complication and becoming a major area of research.
Many factors are assumed to increase the incidence of post-thyroidectomy hypocalcaemia, but
the impact of vitamin D deficiency remains uncertain.
Vitamin D deficiency is known to be one of the most common medical conditions in the world..
Serum calcium is mainly regulated by parathyroid hormone (PTH) and vitamin D, therefore
demonstration of a correlation between preoperative vitamin D levels and the occurrence of
post thyroidectomy hypocalcaemia may reveal an easily correctable factor.
Recently, few studies have investigated whether preoperative vitamin D levels have any
effect on post thyroidectomy hypocalcaemia. Some of them showed that patients with vitamin D
deficiency were more likely to develop postoperative hypocalcaemia. In addition a
significant decrease in postoperative hypocalcemia was shown in patients who received
supplementation of vitamin D regardless of their vitamin D status, while others found no
relationship between preoperative vitamin D concentrations and postoperative hypocalcaemia .
Since results so far were inconclusive, the goal in this study is to significantly determine
the relation between those two factors.
This study is the first to deal with this issue through patients who underwent total
thyroidectomy that was performed by the same surgeon and the same surgical technique.
Study objective
1. To identify a correlation between pre-operative vitamin D deficiency and the occurrence
of hypocalcaemia following total thyroidectomy.
2. To determine wether the correction of vitamin D levels prior to the surgery was able to
prevent post surgery hypocalcaemia.
Study design A retrospective evaluation study of patients who underwent total thyroidectomy
at the head and neck unit of the Otorhinolaryngology department at our institution between
January 2013 and October 2016.
A total number of 60 patients underwent total thyroidectomy with available vitamin D levels
before surgery, as well as pre and post-operative PTH and calcium levels.
Pre-operative vitamin D and PTH levels were checked within a maximum of one month duration
before surgery.
All patients were operated by the same surgeon -Dr. Galit Avior-, with the same surgical
technique.
Methods:
The study involves access to the patients files and admission reports. In addition the
investigators would like to be able to call the patients in order to ask them whether
Vitamin D deficiency was corrected or not before their surgery, and If it was corrected then
when exactly.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04244474 -
Effect of Vitamin D Supplementation on Improvement of Pneumonic Children
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05459298 -
ViDES Trial (Vitamin D Extra Supplementation)
|
N/A | |
| Completed |
NCT04476511 -
The Efficacy and the Safety of Vitamin D3 30,000 IU for Loading Dose Schedules
|
Phase 3 | |
| Suspended |
NCT03652987 -
Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)
|
||
| Completed |
NCT03920150 -
Vitamin D 24'000 IU for Oral Intermittent Supplementation
|
Phase 3 | |
| Completed |
NCT03264625 -
The Effects of Oral Vitamin D Supplementation on the Prevention of Peritoneal Dialysis-related Peritonitis
|
Phase 2 | |
| Completed |
NCT04183257 -
Effect of Escalating Oral Vitamin D Replacement on HOMA-IR in Vitamin D Deficient Type 2 Diabetics
|
Phase 4 | |
| Recruiting |
NCT05084248 -
Vitamin D Deficiency in Adults Following a Major Burn Injury
|
Phase 4 | |
| Completed |
NCT05506696 -
Vitamin D Supplementation Study
|
N/A | |
| Completed |
NCT00092066 -
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
|
Phase 3 | |
| Completed |
NCT03234218 -
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study
|
||
| Completed |
NCT02714361 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
|
N/A | |
| Completed |
NCT03203382 -
Corneal Nerve Structure in Sjogren's
|
||
| Completed |
NCT02906319 -
Vitamin D and HbA1c Levels in Diabetic Patients With CKD
|
N/A | |
| Completed |
NCT02118129 -
Vitamin D Among Young Adults: an Intervention Study Using a Mobile 'App'.
|
N/A | |
| Completed |
NCT02187146 -
The Effects of Serum Vitamin D and IVF Outcome
|
N/A | |
| Not yet recruiting |
NCT01419821 -
Vitamin D and Its Affect on Growth Rates and Bone Mineral Density Until Age 5
|
N/A | |
| Completed |
NCT02275650 -
The Role of Narrowband Ultraviolet B Exposure in the Maintenance of Vitamin D Levels During Winter
|
N/A | |
| Completed |
NCT01651000 -
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
|
Phase 3 | |
| Completed |
NCT01688102 -
The Effect of Oral Vitamin D Versus Narrow-Band UV-B Exposure on the Lipid Profile
|
N/A |