Hypocalcemia Clinical Trial
Official title:
Case-control Study of the PTH Homeostasis in Adolescents and Young Adults With Bartter Syndrome
Verified date | June 2012 |
Source | Soroka University Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | Israel: Ministry of Health |
Study type | Observational |
Parathyroid hormone (PTH) gland calcium sensing receptor (CASR) regulates PTH secretion.
CASR is also expressed in nephron thick ascending limb (TAL). Bartter syndrome (BS), a
normotensive hypokalemic tubulopathy, may be due to mutations in different TAL channels,
including the potassium channel ROMK. Mutations in CASR may also cause BS through its
effects on ROMK function. However, it is unknown whether ROMK mutations exert any effects on
CASR function and PTH physiology. Preliminary data from our center shows that PTH levels
were specifically elevated in type II (where ROMK is mutated) and not in type IV (where
another gene, Barttin is defective) BS, without a common explanation. We assume that the
mutation in ROMK may cause a dysregulation of PTH secretion via possible interaction with
CASR.
The purpose of this study is: to investigate the PT-gland function and regulation in BS.
Methods: Patients with BS type II and IV and normal controls will undergo a standard
protocol of controlled ionic hypo- and hypercalcemia, during which PTH secretion, phosphate
balance and calcium excretion will be followed. Calcium Vs PTH response curves will be
generated and compared.
Expected impact and benefit: the results of this study will help understand the mechanisms
of PTH regulation beyond CASR.
Status | Not yet recruiting |
Enrollment | 15 |
Est. completion date | June 2014 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 14 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Bartter syndrome - Normal Vitamin D status Exclusion Criteria: - Age < 14 yrs |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Soroka University medical Center | Beer Sheva |
Lead Sponsor | Collaborator |
---|---|
Soroka University Medical Center | Ben-Gurion University of the Negev |
Israel,
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