Hypnosis Clinical Trial
Official title:
Multimodal Investigation of Distinct Hypnotic States - A Resting-State fMRI Study
Verified date | November 2018 |
Source | University of Zurich |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigation will assess the brain activation connectivity patterns associated with hypnosis and possible hypnotic sub-states by means of functional magnetic resonance imaging (fMRI). For that purpose, 50 healthy participants highly familiar with hypnosis (according to the OMNI-method) will be recruited and tested.
Status | Completed |
Enrollment | 50 |
Est. completion date | September 30, 2018 |
Est. primary completion date | September 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Aged between 18 and 65 - Proficient in German language - Written informed consent after being informed - Familiar with hypnotic states of OMNI-Hypnosis Exclusion Criteria: - Pre-existing neurological and/or psychiatric conditions - History of brain injuries - Alcohol and/or drug abuse - Chronic diseases that require a permanent intake of drugs Additional exclusion criteria for the MRI- and 1H-MRS-experiment: - General contraindications for a participation on a MRI-Experiment (e.g. claustrophobia, pace maker, cochlea implants, insulin pumps) - Hypersensitivity to loud noise - Not being able to lie still during a longer period of time - Foreign metallic objects in the body (e.g. gunshot wounds, metallic particles, metal implants, irremovable piercings) - Pregnancy |
Country | Name | City | State |
---|---|---|---|
Switzerland | University of Zurich | Zurich |
Lead Sponsor | Collaborator |
---|---|
Mike Bruegger |
Switzerland,
Elkins GR, Barabasz AF, Council JR, Spiegel D. Advancing research and practice: the revised APA Division 30 definition of hypnosis. Int J Clin Exp Hypn. 2015;63(1):1-9. doi: 10.1080/00207144.2014.961870. — View Citation
Jensen MP, Jamieson GA, Lutz A, Mazzoni G, McGeown WJ, Santarcangelo EL, Demertzi A, De Pascalis V, Bányai ÉI, Rominger C, Vuilleumier P, Faymonville ME, Terhune DB. New directions in hypnosis research: strategies for advancing the cognitive and clinical neuroscience of hypnosis. Neurosci Conscious. 2017;3(1). pii: nix004. doi: 10.1093/nc/nix004. Epub 2017 Apr 12. — View Citation
McGeown WJ, Mazzoni G, Vannucci M, Venneri A. Structural and functional correlates of hypnotic depth and suggestibility. Psychiatry Res. 2015 Feb 28;231(2):151-9. doi: 10.1016/j.pscychresns.2014.11.015. Epub 2014 Dec 6. — View Citation
Terhune DB, Cleeremans A, Raz A, Lynn SJ. Hypnosis and top-down regulation of consciousness. Neurosci Biobehav Rev. 2017 Oct;81(Pt A):59-74. doi: 10.1016/j.neubiorev.2017.02.002. Epub 2017 Feb 4. Review. — View Citation
Varga K, Kekecs Z, Myhre PS, Józsa E. A Neutral Control Condition for Hypnosis Experiments: "Wiki" Text. Int J Clin Exp Hypn. 2017 Oct-Dec;65(4):429-451. doi: 10.1080/00207144.2017.1348833. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Differences in resting state functional connectivity (assessed using fMRI) between the four conditions (control state 1 & 2, hypnotic state 1 & 2) | 90 minutes | ||
Secondary | Differences in heart rate variability (assessed during fMRI measurements) between the four conditions (control state 1 & 2, hypnotic state 1 & 2) | 90 minutes | ||
Secondary | Differences respiratory frequency (assessed during fMRI measurements) between the four conditions (control state 1 & 2, hypnotic state 1 & 2) | 90 minutes |
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