Hypnosis Clinical Trial
Official title:
Multimodal Investigation of Distinct Hypnotic States - A Resting-State fMRI Study
The investigation will assess the brain activation connectivity patterns associated with hypnosis and possible hypnotic sub-states by means of functional magnetic resonance imaging (fMRI). For that purpose, 50 healthy participants highly familiar with hypnosis (according to the OMNI-method) will be recruited and tested.
Despite the growing number of studies investigating of the physiological underpinnings of
hypnosis by means of neuroimaging methods such as electroencephalography (EEG) positron
emission tomography (PET) and functional magnetic resonance imaging (fMRI), still no
consensus exists regarding the underlying neurophysiological working mechanisms due to high
levels of variability in the data.
Generally, the variability observed in research examining the neurobiological fundamentals of
hypnosis could be attributed to the following characteristics:
1. Heterogeneity regarding hypnotic induction procedures.
2. Insufficient statistical power.
3. Mono-Modality: Studies investigating the neurophysiologic mechanisms of hypnosis
typically apply only one method for the investigation of their research questions.
However, different techniques complement each other, hence, resulting in a more thorough
understanding of the mechanisms of action.
In this project, the investigators present a multimodal approach, in which these three points
are considered in order to provide a comprehensive picture with respect to psycho- and
neurophysiologic fundamentals of hypnosis and proposed distinct hypnotic states.
Point 1) will be approached by applying a highly reproducible method for the hypnotic
induction (OMNI-hypnosis). This hypnosis method is fast, direct and all OMNI educated
hypnotherapists follow exactly the same induction procedure. This implies a high level of
standardization and operationalization, crucial prerequisites to investigate the phenomenon
based on scientific guidelines.
Point 2) will be addressed by including a homogeneous study sample of 50 highly suggestible
participants. Furthermore, the comparably high number of 50 participants should ensure
sufficient statistical power particularly in consideration of the homogeneity of the study
sample.
Point 3) is addressed by following a multimodal approach combining a vast array of
psychophysiological measures with multimodal neuroimaging. For that purpose, the project will
be divided into three studies: A EEG- and psychophysiological study, a fMRI-study and a
magnetic resonance spectroscopy (1H-MRS) study.
In the present study, fMRI is applied for the investigation of network dynamics associated
with hypnotic states. Hypnotic states will be compared to control states which follow mock
instructions matched to the hypnosis instructions.
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