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Hyperuricemia clinical trials

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NCT ID: NCT06310967 Not yet recruiting - Hyperuricemia Clinical Trials

A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease

Start date: March 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a phase I/II clinical study to evaluate the safety, tolerability, PK, and efficacy of IG3018 tablet in hyperuricemia (HUA) subjects with or without CKD.

NCT ID: NCT06139393 Not yet recruiting - Clinical trials for Gout With Hyperuricemia in Adults

Clinical Study of HR091506 Tablets in Treatment of Gout With Hyperuricemia in Adults

Start date: November 2023
Phase: Phase 3
Study type: Interventional

The study is being conducted to evaluate the efficacy, and safety of HR091506 tablets for treatment of gout with hyperuricemia in adults, and to compare the results with febuxostat tablets in the same doses.

NCT ID: NCT05913310 Not yet recruiting - Hyperuricemia Clinical Trials

Efficacy and Safety of Kui-Yuan Chewable Tablets in Patients With Hyperuricemia

Start date: July 2023
Phase: Phase 4
Study type: Interventional

This study is a multi-center, randomized, double-blinded, controlled trial with two parallel arms. The aim of the study is to evaluate efficacy and safety of Kui-Yuan chewable tablets in patients with hyperuricemia.

NCT ID: NCT05513976 Not yet recruiting - Clinical trials for Primary Gout and Hyperuricemia

Clinical Study of SHR4640 Tablets Combined With Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia

Start date: September 15, 2022
Phase: Phase 2
Study type: Interventional

SHR4640 tablets is a highly selective and potent URAT1 inhibitors,study number is SHR4640-203. The primary purpose of the study is to evaluate the efficacy and safety of the combination of SHR4640 and febuxostat compared with placebo and febuxostat in primary gout and hyperuricemia subjects with inadequate control on febuxostat for 12 weeks.

NCT ID: NCT05476367 Not yet recruiting - Arthritis Knee Clinical Trials

Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty

Start date: August 1, 2022
Phase:
Study type: Observational

We identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level. The knee society score(KSS score) and the hospital for special surgery knee score (HSS score) before the surgery and 6 years after the surgery will be collected. Also the clinical data will be collected.

NCT ID: NCT05454423 Not yet recruiting - Gout Clinical Trials

Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.

NCT ID: NCT05347498 Not yet recruiting - Clinical trials for Primary Gout With Hyperuricemia in Adults

A Trial of HR091506 Tablets in Treatment of Primary Gout With Hyperuricemia in Adults

Start date: April 30, 2022
Phase: Phase 1
Study type: Interventional

The study is being conducted to evaluate the efficacy and safety of HR091506 tablets for treatment of primary gout with hyperuricemia in adults, and to compare the results with febuxostat tablets in the same doses.

NCT ID: NCT05245890 Not yet recruiting - Clinical trials for Non-Alcoholic Fatty Liver Disease

Assocaiton Between Uric Acid Trajecteries and Remission of NAFLD in NAFLD Individuals

Start date: March 1, 2022
Phase:
Study type: Observational [Patient Registry]

Uric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders. A growing body of evidence, comprising a great deal of cross-sectional studies and several prospective ones, also indicates that hyperuricemia is associated with increased prevalence, incidence, and disease severity of non-alcoholic fatty liver disease (NAFLD). Capitalizing on a cohort study in China, the investigators are aimed to assess the associations of SUA trajecteries with remission of NAFLD in NAFLD individuals and examined whether the association differs across subpopulations.

NCT ID: NCT04799925 Not yet recruiting - Hyperuricemia Clinical Trials

Hyperuricemia and Diabetic Nephropathy

Start date: April 15, 2021
Phase:
Study type: Observational

The purpose of the study is to detect the effect of treatment of hyperuricemia on eGFR (Estimated Glomerular Filtration Rate) as an objective criterion for assessment of progression of diabetic nephropathy in patients with Type 2 Diabetes Mellitus.

NCT ID: NCT04586803 Not yet recruiting - Hyperuricemia Clinical Trials

Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers

Start date: October 2020
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to evaluate the relative bioavailability of three different prescription processes of SHR4640 tablets in healthy volunteers. The secondary objective of the study is to observe the safety of SHR4640 tablets in healthy subjects.