Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

Hypertrophy Clinical Trial

— KIPLING  

Official title:

Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05774444
• Other study ID #: KIPLING
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2023
• Est. completion date: December 25, 2024

Study information

• Verified date: May 2023
• Source: University of Glasgow
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 48
• Est. completion date: December 25, 2024
• Est. primary completion date: December 25, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• Be 60 years old or older
• Have a BMI of less than 35kg/m2
• Be participating in structured exercise for less than 2h per week

Exclusion Criteria:

• Diabetes
• Severe cardiovascular disease
• Seizure disorders,
• Uncontrolled hypertension (>150/90mmHg at baseline measurement)
• Cancer or cancer that has been in remission <5 years
• Ambulatory impairments which would limit ability to perform assessments of muscle function
• Dementia
• Taking medication known to affect muscle (e.g., steroids)
• Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
• Anticoagulant therapy
• Allergies to seafood
• Regular consumption of more than 1 portion of oily fish per week.

Related Conditions & MeSH terms

• Hypertrophy

Intervention

Dietary Supplement:
• Krill oil
Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.
• Krill protein
Krill protein will be given to the participant following a resistance exercise bout.
• Vegetable oil
This will be the control against the Krill oil
• Carbohydrate
This will be the control for the Krill protein

Locations

Country	Name	City	State
United Kingdom	Stuart Robert Gray	Glasgow

Sponsors (2)

Lead Sponsor	Collaborator
University of Glasgow	Aker BioMarine

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-exercise muscle protein synthesis	Muscle protein synthesis measured 3-7h after a single bout of resistance exercise	3-7 hours
Secondary	Change in Muscle thickness	Vastus lateralis muscle thickness measured by ultrasound	Change from baseline to 8 weeks
Secondary	Change in grip strength	Grip strength measured with a Jamar dynamometer	Change from baseline to 8 weeks
Secondary	Change in fat mass	Whole body fat mass measured by BIA	Change from baseline to 8 weeks
Secondary	Change in lean mass	Whole body lean mass measured by BIA	Change from baseline to 8 weeks
Secondary	Change in muscle strength	Knee extensor muscle strength measured isometrically	Change from baseline to 8 weeks
Secondary	Change in Chair rise time	Time taken to get up and down from a chair 5 times	Change from baseline to 8 weeks
Secondary	Change in balance	Ability to stand for 10 seconds in full tandem, semi-tandem and feet together	Change from baseline to 8 weeks
Secondary	Change in gait speed	Time taken to walk 4 metres at a normal walking pace	Change from baseline to 8 weeks
Secondary	Basal muscle protein synthesis	Muscle protein synthesis measured from 0-3h after an overnight fast	0-3 hours
Secondary	Change in Erythrocyte fatty acid profile	Erythrocyte fatty acid profile	Change from baseline to 8 weeks