Hypertrophy Clinical Trial
— SPARTAOfficial title:
Does Protein and Polyphenol Supplementation Augment Adaptations to 30 Sessions of Resistance Exercise Training in Healthy Males and Females Compared to an Isoenergetic Placebo Supplement?
Verified date | March 2020 |
Source | University of Exeter |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Chronic resistance training has been shown to increase muscle cross-sectional area, volume
and strength. Individuals participating in a resistance training program may wish to consume
protein supplements to aid recovery and maximise adaptation. Furthermore, antioxidants have
been shown to aid recovery from acute bouts of exercise. However, the effect of antioxidants
combined with protein on long term-training adaptation is not fully understood.
This study will combine measures of muscle size, muscle strength and function, and the
underlying changes in muscle metabolism in order to assess the effect of consuming a combined
protein-antioxidant supplement during a 30 session resistance training program.
Status | Completed |
Enrollment | 32 |
Est. completion date | December 21, 2019 |
Est. primary completion date | December 21, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Male and Female - 18 - 40 years of age - Recreationally active Exclusion Criteria: - Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes). Such impairments can affect skeletal muscle metabolism - Any diagnosed cardiovascular disease or hypertension - Use of nutritional supplements (e.g. protein, polyphenols, vitamins, antioxidants) as use of nutritional supplements during the study period may interfere with the physiological responses to the supplements of interest administered in this study. - Habitual dietary protein intake <0.8 g/kg/day or >1.6 g/kg/day as calculated with a three day diet diary. Habitually low protein may impair adaptations to resistance exercise training and a habitually excessive protein intake may negate the benefit of protein supplementation. - Current musculoskeletal injury that may impair exercise performance or may be exacerbated due to this studies exercise protocol. - Resistance trained (participating in structured resistance exercise 3 or more times per week for >6 months), endurance trained (participating in structured endurance exercise for >6h per week for >6 months), or sedentary participants as these are not the populations of interest. - Chronic use of anti-inflammatory medicines prior to the study and unwillingness to refrain from taking anti-inflammatory medications during the study as these medications may affect skeletal muscle metabolism and/or adaptation to exercise. - Individuals who carry an epi-pen, or those with a diagnosed allergy or who believe that they have an allergy to milk or milk products, crustacean shellfish, tree nuts, or peanuts - Individuals with a severe allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients - Individuals with non removable metallic implants (including heart pacemaker, cochlea implants, medication pumps, surgical clips, plates or screws) or claustrophobia |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Exeter | Exeter | Devon |
Lead Sponsor | Collaborator |
---|---|
University of Exeter |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in cross-sectional area of quadriceps muscle group | The cross-sectional area of the muscles comprising the thigh after 30 training sessions will be compared to pre-training values. This will be measured using MRI. | After 30 training sessions (approx. 10 weeks) | |
Secondary | Change in quadriceps muscle group volume | The volume of the muscles comprising the thigh after 30 training sessions will be compared to pre-training values. This will be measured using MRI. | After 30 training sessions (approx. 10 weeks) | |
Secondary | Change in knee extensor isokinetic total work | Bilateral knee extensor isokinetic total work will be assessed before and after the training program by quantifying work completed over 30 isokinetic quadriceps contractions on an isokinetic dynamometer. | After 30 training sessions (approx. 10 weeks) | |
Secondary | Change in maximal isometric peak torque | Knee extensor isometric peak torque will be assessed before and after the training program using an isokinetic dynamometer. | After 30 training sessions (approx. 10 weeks) | |
Secondary | Change in maximal isokinetic peak torque | Knee extensor isokinetic peak torque over 3 repetitions will be assessed before and after the training program using an isokinetic dynamometer. | After 30 training sessions (approx. 10 weeks) | |
Secondary | Change in muscle protein synthesis assessed using the stable isotope Deuterium Oxide | The enrichment of deuterated alanine (from the deuterium oxide heavy water stable isotope tracer) in vastus lateralis biopsy samples will be measured relative to the non-deuterated alanine. The change over 48 hours will be measured pre- and post-training to calculate a fractional synthesis rate (% day). | After 30 training sessions (approx. 10 weeks) | |
Secondary | Perceived quadriceps muscle soreness: | Soreness will be assessed at the start of each training session using a validated visual analogue scale (VAS) | After 30 training sessions (approx. 10 weeks) |
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