Egyptian Hypertrophic Cardiomyopathy Program

Status Recruiting

Clinical Trial Summary

Egyptian HCM program aims at defining incidence, severity, phenotype, genotype and determinants of the disease in Egypt, and providing state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

Clinical Trial Description

This project aims to: - Define incidence, severity, phenotype, genotype and determinants of the disease in Egypt. - Characterise the phenotype and genotype of several large cohorts with inherited muscle disease and their relatives. - Provide state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific. - Study the basic mechanisms responsible for the different phenotypes at a molecular and cellular level including genotype-phenotype correlation. - Provide a special focus for studying patients who are genotype positive and phenotype negative which we believe could yield critical data regarding the evolution of the disease. - Develop sophisticated laboratory studies for single cell electrophysiology and immunocytochemistry and others focusing on the explanted human material from the surgical program. - Define the role of microvascular coronary artery in the development and progression of the disease. - Training Egyptian cardiologists, cardiac surgeons and scientists on state-of-the-art diagnosis and management of heart muscle disease including the latest developments in imaging, novel surgical techniques, coronary physiology, next generation sequencing, bioinformatics and cellular electrophysiology. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05884892
Study type	Observational [Patient Registry]
Source	Magdi Yacoub Heart Foundation
Contact	Magdi H Yacoub, FRS OM
Email	m.yacoub@imperial.ac.uk
Status	Recruiting
Phase
Start date	January 1, 2014
Completion date	January 1, 2030

View Details

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