Egyptian Hypertrophic Cardiomyopathy Program

Hypertrophic Cardiomyopathy Clinical Trial

Official title: Egyptian Hypertrophic Cardiomyopathy Program

Status Recruiting

Clinical Trial Summary

Egyptian HCM program aims at defining incidence, severity, phenotype, genotype and determinants of the disease in Egypt, and providing state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

Clinical Trial Description

This project aims to:

• Define incidence, severity, phenotype, genotype and determinants of the disease in Egypt.

• Characterise the phenotype and genotype of several large cohorts with inherited muscle disease and their relatives.

• Provide state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

• Study the basic mechanisms responsible for the different phenotypes at a molecular and cellular level including genotype-phenotype correlation.

• Provide a special focus for studying patients who are genotype positive and phenotype negative which we believe could yield critical data regarding the evolution of the disease.

• Develop sophisticated laboratory studies for single cell electrophysiology and immunocytochemistry and others focusing on the explanted human material from the surgical program.

• Define the role of microvascular coronary artery in the development and progression of the disease.

• Training Egyptian cardiologists, cardiac surgeons and scientists on state-of-the-art diagnosis and management of heart muscle disease including the latest developments in imaging, novel surgical techniques, coronary physiology, next generation sequencing, bioinformatics and cellular electrophysiology. ;

Related Conditions & MeSH terms

• Cardiomyopathies
• Cardiomyopathy, Hypertrophic
• Hypertrophic Cardiomyopathy
• Hypertrophy

• NCT number: NCT05884892
• Study type: Observational [Patient Registry]
• Source: Magdi Yacoub Heart Foundation
• Contact: Magdi H Yacoub, FRS OM
• Email: m.yacoub@imperial.ac.uk
• Status: Recruiting
• Start date: January 1, 2014
• Completion date: January 1, 2030