Hypertrophic Cardiomyopathy Clinical Trial
Official title:
Risk Stratification Using Positron Emission Tomography (PET) in Hypertrophic Cardiomyopathy (HCM)
The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to ventricular arrhythmias detected by the implantable cardioverter defibrillator (ICD). This could potentially lead to an improved risk stratification of HCM patients.
Positron Emission Tomography (PET) is a functional imaging technique that utilizes
radioactive tracers to gain information on physiological or pathophysiological processes in
vivo. Different tracers can provide information on different processes of interest. In
cardiology, metabolic processes consuming oxygen (aerobic) can be studied with
11-Carbon-Acetate, sympathetic innervation can be studied with 11-Carbon-hydroxyephedrine and
using 15-Oxygen-water the myocardial blood flow. Structural information of the heart such as
left ventricular mass, left ventricular volumes and wall thickness can also be calculated
with PET.
The aim is to correlate PET parameters and burden of ventricular arrhythmias in order to
improve risk stratification in HCM.
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