A First in Human Study of STT-5058, an Antibody That Binds ApoC3

Status Terminated

Clinical Trial Summary

A First in Human Study of STT-5058, an Antibody That Binds ApoC3, investigating single and multiple ascending intravenous doses and ascending subcutaneous doses of STT-5058 in otherwise healthy volunteers with elevated triglyceride levels

Clinical Trial Description

The study is in five parts. Part A is up to 6 single ascending intravenous dose cohorts of STT-5058 in otherwise healthy volunteers with TRGs >150mg/dL. Part B is up to 4 multiple ascending intravenous dose cohorts of STT-5058 in otherwise healthy volunteers with TRGs >150mg/dL who will receive 3 doses at 2 week intervals. Part C will recruit a single cohort of patient volunteers with TRG >200mg/dL who will receive 3 doses at 2 week intervals of STT-5058. Part D will investigate up to 2 single ascending doses of subcutaneous STT-5058. Part E will recruit a single cohort of otherwise healthy volunteers with TRG > 150mg/dL to receive 4 doses subcutaneously of STT-5058 over 4 weeks ;

Study Design

Related Conditions & MeSH terms

Hypertriglyceridemia

Clinical Trial Details

NCT number	NCT04419688
Study type	Interventional
Source	Staten Biotechnology BV
Contact
Status	Terminated
Phase	Phase 1
Start date	May 26, 2020
Completion date	December 23, 2022

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