Hypertriglyceridemia Clinical Trial
Official title:
Randomized, Controlled, Open-label Trial of Intravenous Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis.
The aim of this study is to investigate the therapeutic efficacy of intensive insulin in patients with hypertriglyceridemia induced moderate/severe acute pancreatitis on the course and outcome of disease.
Hypertriglyceridemia-induced acute pancreatitis occurs in about 1-4% of the cases. It is the
third leading cause of pancreatitis after biliary and alcoholic etiology.
Hypertriglyceridemia can be caused by primary causes, lipid metabolism disorders and
secondary causes.
Hyperlipidemic pancreatitis can be provoked when triglyceride levels (TGL) exceed 11.3 mmol/l
(1,000 mg/dl). Except for standard symptomatic treatment, plasmapheresis and insulin have
been performed to rapidly reduce TGL and chylomicron levels in the blood.The therapeutic
efficacy of intensive insulin, standard insulin, and plasmapheresis in patients with
hypertriglyceridemia induced moderate/severe acute pancreatitis on the course and outcome of
disease.After acceptance patients will be randomized by random envelope in the 3 groups:
Group A: intensive insulin (glycemic control 4.4-6.1mmol/L), Group B: standard insulin
(glycemic control 7.8-10.0 mmol/L), and Group C: plasmapheresis.
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