Hypertriglyceridemia Clinical Trial
Official title:
Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study
Bexarotene is a RXR-selective retinoid, licensed for the treatment of cutaneous T cell lymphoma. The most frequent adverse effect is hypertriglyceridemia but its mechanism is not well known. The purpose of this study is to research a carbohydrate metabolism disorder associated in bexarotene-induced hypertriglyceridemia.
Primary cutaneous lymphomas are the second group of extra nodal lymphomas after
gastrointestinal lymphomas. Bexarotene is licensed for the treatment of epidermotropic
cutaneous T cell lymphoma .The most common side effect of bexarotene is hypertriglyceridemia
(82%) associated with hypercholesterolemia (30 to 40%). Central hypothyroidism is also
present in 40-80% of cases. These adverse effects are dose-dependent. The management of
hyperlipidemia induced by bexarotene is difficult. The mechanism of lipid disorder induced by
bexarotene is not well known. Associated carbohydrate metabolism disorder could be present
and play a role in the bexarotene-induced hyperlipidemia.
The main objective is to estimate the frequency of a carbohydrate disorder in patients with
hypertriglyceridemia (TG> 1.5 g / L) induced by bexarotene treatment of cutaneous T cell
lymphoma, previously free of diabetes, thyroid dysfunction and dyslipidemia.
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