Regulation of Sterol Homeostasis

Status Completed

Clinical Trial Summary

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

Clinical Trial Description

n/a

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Hypertriglyceridemia

Clinical Trial Details

NCT number	NCT00018720
Study type	Observational
Source	VA Office of Research and Development
Contact
Status	Completed
Phase	N/A
Start date	April 1996
Completion date	December 2000

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