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Hypertonic Saline clinical trials

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NCT ID: NCT06226402 Recruiting - Clinical trials for Acute Respiratory Distress Syndrome

Effect of Nebulized and Intravenous Hypertonic Saline 3% on the Management of Patients With Acute Respiratory Distress Syndrome

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

The aim of our study is to compare between the effect of nebulized and intravenous injection of hypertonic saline 3% on the outcome of patients with acute respiratory distress syndrome.

NCT ID: NCT04686344 Completed - Hypertonic Saline Clinical Trials

Point of Care Optic Nerve Sheath Ultrasound to Assess Intracranial Pressure

Start date: December 21, 2020
Phase: Early Phase 1
Study type: Interventional

Elevated intracranial pressure (ICP) is one of the most common symptoms encountered in a variety of traumatic injuries and diseases. Any tissue swelling within the rigid confines of the skull results in increased ICP, which may lead to life-threatening structural alterations in the brain or cerebral blood flow, thus causing oxygen deprivation and ischemia in the brain. Methods for ICP monitoring can be divided into invasive and noninvasive approaches. In fluid-based systems, external ventricular drainage (EVD) has been considered the gold standard. Clinicians have found several noninvasive methods that can be used as surrogates for invasive methods for ICP measurement. The optic nerve, as part of the central nervous system, is wrapped by the dural sheath. The optic nerve sheath (ONS) is the continuation of the subarachnoid space at the optic nerve, and its tissues are connected with the subarachnoid space. Thus, an increase in ICP results in a corresponding elevation of the ONS diameter (ONSD). Hypertonic solutions such as mannitol and hypertonic saline (HTS) are recommended early in the management of ICH after severe TBI . They provide therapeutic benefit along with a wide therapeutic margin. The most recent BTF guidelines stated "although hyperosmolar therapy may lower intracranial pressure, there was insufficient evidence about effects on clinical outcomes to support a specific recommendation, or to support use of any specific hyperosmolar agent".

NCT ID: NCT04439994 Completed - Hypertonic Saline Clinical Trials

Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)

miRNA
Start date: November 1, 2020
Phase: N/A
Study type: Interventional

In this experiment, the investigators would like to test the following: 1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ? 2. Can these canges correlate with the development of local hyperalgesia? 3. How does the plasma miRNA expression change over a duration of 24 hours post pain induction ? 4. Which mRNA targets are potentially affected by acute pain?

NCT ID: NCT04146311 Completed - Knee Pain Chronic Clinical Trials

Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee Pain

Start date: October 30, 2019
Phase: N/A
Study type: Interventional

The objects of this research are to investigate the ability of the motor learning and test the possible differences between younger and older healthy human, and between non-pain and acute experimental pain and chronic clinical pain conditions.