Hyperthyroidism Clinical Trial
Official title:
Coexisting Thyroid Disease and Hyperparathyroidism
Purpose: Prospective studies of patients with hyperparathyroidism are warranted to determine
the prevalence of concurrent thyroid disease applying the current standard of pre-operative
radioscintigraphic and sonographic imaging of the neck. Timely diagnosis and treatment of
co-existing thyroid disease is advantageous given the well-established increased morbidity
associated with a second neck exploration. The purpose of this study is to determine the
prevalence and specific type of thyroid disease in patients with hyperparathyroidism, and to
determine the frequency with which the presence of thyroid disease alters the treatment plan
for patients with hyperparathyroidism.
Research Design: This will be a prospective single arm observational study of up to 200
military health care beneficiaries over the age of 18 years with primary and secondary
hyperparathyroidism scheduled to undergo parathyroid resection.
Methodology: Patients will undergo standard pre-operative imaging of the neck including
ultrasonography and 99mTc-sestamibi scintigraphy. An operative plan will be developed based
on the information obtained from history, physical examination, laboratory studies, and
imaging studies. The number and type of thyroid disease in these patients will be determined
based on these non-invasive studies (Objective A). A change in the otherwise standard
treatment will include those patients having partial or complete resections of their thyroid
glands because: a) the patients would have undergone minimally invasive surgery if not for
the results of the imaging studies, and, b) the patients who would have undergone 3 ½ gland
parathyroidectomy if not for the results of the imaging studies (Objective B).
n/a
Observational Model: Cohort, Time Perspective: Prospective
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