Hyperthyroid Clinical Trial
Official title:
Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Pregnancy
1. MAIN OBJECTIVE :
To assess the consequences of a maternal hyperthyroïd during pregnancy on intellectual
development of the child from 6 to 9 years
2. SECONDARY OBJECTIVES :
1. To assess the consequences of a maternal hyperthyroïd during pregnancy on the
capacities of attention, learning process and the degree of hyperactivity of the
child from 6 to 9 years.
2. To study if it exist differences of intellectual development, capacities of
attention, learning process, and degree of hyperactivity in the child from 6 to 9
years, born to hyperthyroid mother during pregnancy, according to:
- the etiology of the maternal hyperthyroïd (transitory gestation hyperthyroid
versus disease of Basedow),
- the use or not of a anti-thyroid treatment,
- the rate of TSH néonatal (measured with the blotter by tracking with J3 at all
the new born ones).
1. INCLUSION CRITERIA :
- Old from 6 to 9 years included
- Age of gestation between ≥37 and <41 weeks of amenorrhoea
- Born from a mono-foetale pregnancy
- Euthyroïd at the time of the entry in the study
- Provided education for at the elementary school on a level adapted to its age
2. NON INCLUSION CRITERIA :
- Presenting a congenital hypothyroïd or a known thyroid dysfonction at the time of
the entry in the study
- Carrier of a chronic pathology (organic or psychological) or malformative severe
- Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st
degree
3. EXCLUSION CRITERIA :
o Discovered of a thyroid dysfonction at the time of the entry in the study
4. STRATEGIES / PROCEDURES :
Multicentric, comparative study of a troop of child born to hyperthyroïd mothers during
pregnancy (children exposed to the maternal hyperthyroïd) and children born to euthyroïd
mothers during pregnancy (nonexposed children with the maternal hyperthyroïd).
- 1st part of the study: Retrospective analyze of the files of symptomatic hyperthyroid
mothers during pregnancy.
- 2nd part of the study: Assessment of intellectual development, capacities of attention,
learning process and degree of hyperactivity of the children between 6 and 9 years. The
exposed children (born to hyperthyroïd mothers during pregnancy) will be compared with
nonexposed children (born to euthyroïd mothers during pregnancy).
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