Clinical Trials Logo

Clinical Trial Summary

Excessive diurnal sleepiness is characterized by an incapacity to stay awake, in favour of sleep occurrence. This sleepiness might be secondary to a sleep disorder; when it is not the case, we talk about primary hypersomnia (including narcolepsy and idiopathic hypersomnia). To date, objective measures of sleepiness can only be achieved in laboratory. Subjective techniques as scales and questionnaires are highly sensitive to inter-individual differences and cannot constitute a reliable diagnosis tool of sleepiness. Recent studies suggested that some salivary biomarkers are sensitive to sleep characteristics and thus, may allow the objective and easy evaluation of sleepiness. The objective of the study is to explore the usability of salivary biomarkers (a-amylase and oxalate) as a new non-invasive technique to evaluate sleepiness and to diagnose primary hypersomnia in children. The hypothesis of this study is that there will be a modification of salivary biomarkers concentrations with the variations of diurnal sleepiness.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05183464
Study type Observational
Source Hospices Civils de Lyon
Contact Patricia FRANCO, PU,PH
Email [email protected]
Status Not yet recruiting
Start date April 1, 2022
Completion date April 1, 2025

See also
  Status Clinical Trial Phase
Withdrawn NCT03626727 - Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia Early Phase 1
Completed NCT01183312 - Flumazenil for the Treatment of Primary Hypersomnia Phase 1/Phase 2
Terminated NCT03198156 - Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy N/A
Completed NCT03682185 - The Healthy Patterns Sleep Study Phase 3
Completed NCT00916253 - Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies N/A
Completed NCT04157244 - The Music, Sleep and Dementia Study N/A
Completed NCT01877616 - Sleep Disorders and Their Cardiovascular Correlates in Atahualpa. N/A
Suspended NCT00427323 - Light Exposure to Treat Sleep Disruption in Older People N/A
Not yet recruiting NCT04300166 - Telemedicine and Humidification for Cpap IN Osas Key Treatment (THINK Study) N/A
Completed NCT01146600 - Clarithromycin for the Treatment of Hypersomnia Phase 2
Completed NCT01764035 - Mindfulness Therapy on Disrupted Sleep in Bipolar Disorder N/A
Completed NCT03459300 - Importance of Sleep Deprivation in Differential Diagnosis of Primary Hypersomnia (Actisom dépistage)
Completed NCT00001664 - Sleep Disorders of Patients With Diseases of the Nervous System N/A
Recruiting NCT04201392 - Sleep in Psychiatric Inpatients
Terminated NCT01544465 - Structured Physical Activity for Sleep Quality and Daytime Sleepiness in Patients With Parkinson's Disease N/A