Hyperparathyroidism Clinical Trial
Official title:
Gene Expression in Hyperparathyroidism: Identifying Molecular Differences in MEN1 Patients Versus Young MEN1 Negative Patients
Verified date | May 2019 |
Source | M.D. Anderson Cancer Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Objectives:
1. To better define the differences in molecular genetics of parathyroid tumors in patients
with MEN1, single gland parathyroid disease in patients less than 50 years old and
single gland disease in patients greater than 50 years old.
2. To better define the incidence of HRPT2 mutation in young patients with primary
hyperparathyroidism and determine whether routine testing in these patients is
indicated.
Status | Terminated |
Enrollment | 22 |
Est. completion date | October 18, 2017 |
Est. primary completion date | October 18, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. All patients previously enrolled in parathyroid tissue banking under protocol Lab08-0034. 2. For the subgroup designated for HRPT2 mutation testing: Patients with primary hyperparathyroidism who are younger than 50 years of age and have tested negative for MEN1, between January 1, 1980 and the present. Exclusion Criteria: N/A |
Country | Name | City | State |
---|---|---|---|
United States | University of Texas MD Anderson Cancer Center | Houston | Texas |
Lead Sponsor | Collaborator |
---|---|
M.D. Anderson Cancer Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Molecular Genetics of Parathyroid Tumors | RNA isolated from banked frozen tissues. cDNA microarray prepared using an Illumina array chip. Results analyzed using Ingenuity analysis software to detect 2-fold changes in gene expression. T-statistics used to determine significantly discriminating genes. | 10 years | |
Secondary | HRPT2 Mutations | Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients stained for parafibromin to evaluate for HRPT2 mutations. | 10 years |
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