The Effect of Hyperoxia on Cardiac Output

Status Completed

Clinical Trial Summary

Rational: Preoxygenation is a standard procedure before (deep) sedation in the ED. However, there is literature suggesting that too much oxygen can be harmful. One potential detrimental effect is a decrease in cardiac output due to coronary vasoconstriction. So far, it is unknown if this effect is rate dependent and if it also occurs after only a short period of hyperoxia, as patients experience during procedural sedation pre-oxygenation.

Objective: To investigate if hyperoxia has a negative effect on Cardiac index (CI) in patients undergoing procedural sedation in the ED.

Clinical Trial Description

Methods: In patients needing sedation for a painful condition, non-invasive measurements of CI, stroke volume and total peripheral resistance are performed using the Clearsight non-invasive cardiac output monitoring system.. Measurements will be taken at baseline, after 1,2 and 5 minutes of 15L O2/min, and then after another 2 and 5 minutes of flush rate oxygen and during the subsequent sedation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03930979
Study type	Observational [Patient Registry]
Source	Medical Centre Leeuwarden
Contact
Status	Completed
Phase
Start date	May 1, 2018
Completion date	June 7, 2019

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