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Hypernatremia clinical trials

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NCT ID: NCT06061783 Not yet recruiting - Hypernatremia Clinical Trials

Correction of Hypernatremia by Intravenous Hypotonic Solution Compared to Enteral Water

Start date: November 30, 2023
Phase: N/A
Study type: Interventional

Hypernatremia, defined as an elevation of serum sodium >145 mEq/L, is one of the most common electrolyte disturbances in hospitalized patients and intensive care units. In this study, the investigator aims, for the first time, to compare two strategies used for the correction of hypernatremia, using intravenous hypotonic solution compared to naso- or orogastric tube enteral water.

NCT ID: NCT06037928 Recruiting - Critical Illness Clinical Trials

Plasma Sodium and Sodium Administration in the ICU

Start date: September 4, 2023
Phase:
Study type: Observational

Patients in the Intensive Care Unit often present with low levels of plasma sodium and are therefore often administered high amounts of sodium, both as an additive to intravenous glucose solutions and as a constituent of various drugs and infusion fluids. Recent findings question the benefit of these large quantities of sodium and raise the question whether the individual physician takes the total sodium administration into account when sodium additives are prescribed. It can also be suspected that sodium prescription differs significantly between physicians.

NCT ID: NCT05818826 Recruiting - Septic Shock Clinical Trials

Early Versus Conventional Cessation of Hydrocortisone in Septic Shock

CESSHYDRO
Start date: July 5, 2023
Phase: Phase 2
Study type: Interventional

Septic shock is one of the causes of death in ICU and hospital. Refractory shock is the problem which healthcare providers should recognize though it is difficult to handle with. The corticosteroid called hydrocortisone is one of the treatment in refractory septic shock which requires vasopressor to maintain blood pressure. In recovery phase of septic shock and weaning off vasopressor, there is no definite way to taper off hydrocortisone.

NCT ID: NCT05735457 Not yet recruiting - Clinical trials for Cardiovascular Risk Factor

A Short, Animated Storytelling Video to Increase Knowledge About Sodium Intake as a Cardiovascular Risk Factor

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This study will evaluate the effect of a short, animated storytelling intervention video on sodium intake as a major risk factor for cardiovascular disease on immediate and medium-term retention of knowledge about the risks of cardiovascular diesaes due to increased sodium intake. We will also measure voluntary engagement with the content of the short, animated storytelling intervention video on positive psychological capital. In this 4-armed, parallel, randomized controlled trial, 10,000 adult, US participants will be randomly assigned to (1) a short, animated storytelling intervention video on sodium as a cardiovascular disease risk factor followed by surveys assessing the facts om sodium and cardiovascular disease conveyed in the video (2) the surveys only, (3) an attention placebo control video followed by the before mentioned surveys, and (4) an arm that is exposed to neither the video nor the surveys. Two weeks later, participants in all four arms will complete all of the surveys. The primary outcome is knowledge about the cardiovascular disease risk associated with increased sodium intake (immediate and medium-term). The major scondary outcome is the extent of voluntary engagement with the short, animated storytelling video content.

NCT ID: NCT05591612 Not yet recruiting - Healthy Nutrition Clinical Trials

Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

Food Intake Study: This will be a 4-week randomized controlled intervention study with a vegetable intake questionnaire, daily food intake, and seasoning usage measurement to test the acceptability of different seasoning ingredients and vegetable intake in healthy adults. Participants will be randomly assigned to one of three groups (a) vegetables prepared with MSG to replace some of the NaCl content (MSG group); (b) vegetables prepared with only NaCl (NaCl group); (c) vegetables prepared with potassium chloride to replace some of the NaCl content (KCl group). Sensory Evaluation Study: A sensory evaluation utilizing all seasoning methods from the intervention will be conducted at a Texas Tech University culinary education lab. In a Texas Tech University culinary education lab, 2-4 vegetables will be cooked and seasoned with either MSG, NaCl, or KCI for taste testing. Then, using a standardized form, participants will rate their acceptability and preference of each vegetable, including sensory characteristics such as appearance, color, odor, texture, and flavor.

NCT ID: NCT05092854 Completed - Heat Stress Clinical Trials

The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress

AMP2
Start date: September 3, 2021
Phase: N/A
Study type: Interventional

The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the heat while resting and during light/moderate aerobic exercise. A secondary purpose is to examine these same effects with two differing dosage patterns of the lotion. A tertiary purpose is to investigate the effect of an amino acid rehydration beverage in comparison to a placebo on measurements of hydration, subjective assessments of stress, and vestibular as well as musculoskeletal measures of fatigue for up to 24-hours after the completion of both passive and exertional heat stress within a dehydrated state.

NCT ID: NCT05090020 Recruiting - Clinical trials for Echinococcosis, Hepatic

Hypernatremia in Hydatid Cyst Treatment

Start date: February 1, 2021
Phase:
Study type: Observational

Hypertonic saline (HS) is one of the most widely used scolocidal agents in the treatment of hydatid cysts. Hypernatremia is one of the complications associated with the use of HS. It can cause hypernatremia, acid-base disorder, impaired lung, renal, cardiac and neurological functions and even death. Therefore, caution should be exercised in the use of HS, and open technique should be preferred in surgery.

NCT ID: NCT05085223 Not yet recruiting - Critical Illness Clinical Trials

Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients

HYPNIC II
Start date: October 2021
Phase:
Study type: Observational

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis. This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.

NCT ID: NCT05079789 Terminated - Edema Clinical Trials

Amiloride in Nephrotic Syndrome

AMILOR
Start date: June 8, 2020
Phase: Phase 3
Study type: Interventional

The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide.

NCT ID: NCT04949139 Recruiting - Hypernatremia Clinical Trials

Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction in Patients With Severe Hypernatremia

SALSAII
Start date: May 1, 2021
Phase: Phase 4
Study type: Interventional

This study will evaluate the efficacy and safety of rapid intermittent correction and slow correction with an electrolyte-free solution in patients with severe hypernatremia (glucose-corrected serum sodium, ≥ 155 mmol/L).