Hyperlipidemias Clinical Trial
Official title:
Association Between the Triglyceride-glucose Index and the Ratio of Triglyceride to High-density Lipoprotein Cholesterol With Fetal Macrosomia in Low-risk Nulliparous Pregnant Women
Verified date | June 2024 |
Source | Ankara Etlik City Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus. The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality. While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.
Status | Active, not recruiting |
Enrollment | 302 |
Est. completion date | July 30, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG). - Low-risk nulliparous singleton pregnant women. - Age between 18 and 40 years old Exclusion Criteria: - Post-term pregnancies - Hospitalized for preterm labor or preterm premature rupture of membranes. - Gestational diabetes mellitus, diabetes mellitus type I - type II. - Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia. - Multiparous pregnant women - Multiple pregnancies - Pregnant women with chronic diseases. - Pregnant women with impaired liver function; - Pregnant women with body mass index <25 and >40 kg/m2. |
Country | Name | City | State |
---|---|---|---|
Turkey | Ankara Etlik City Hospital | Ankara | Yenimahalle |
Lead Sponsor | Collaborator |
---|---|
Ankara Etlik City Hospital |
Turkey,
Babic N, Valjevac A, Zaciragic A, Avdagic N, Zukic S, Hasic S. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Med Arch. 2019 Jun;73(3):163-168. doi: 10.5455/medarh.201 — View Citation
Barat S, Ghanbarpour A, Bouzari Z, Batebi Z. Triglyceride to HDL cholesterol ratio and risk for gestational diabetes and birth of a large-for-gestational-age newborn. Caspian J Intern Med. 2018 Fall;9(4):368-375. doi: 10.22088/cjim.9.4.368. — View Citation
Macrosomia: ACOG Practice Bulletin, Number 216. Obstet Gynecol. 2020 Jan;135(1):e18-e35. doi: 10.1097/AOG.0000000000003606. — View Citation
Poveda NE, Garces MF, Darghan AE, Jaimes SAB, Sanchez EP, Diaz-Cruz LA, Garzon-Olivares CD, Parra-Pineda MO, Bautista-Charry AA, Muller EA, Alzate HFS, Acosta LMM, Sanchez E, Ruiz-Parra AI, Caminos JE. Triglycerides/Glucose and Triglyceride/High-Density L — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The TyG index | The triglyceride-glucose index was determined using the formula Ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2], with blood samples taken from pregnant women in the third trimester. | between 28 and 40 weeks of pregnancy | |
Primary | The triglyceride to high density lipoprotein cholesterol ratio | The triglyceride to high density lipoprotein cholesterol ratio was calculated from the blood samples taken from pregnant women in the third trimester. | between 28 and 40 weeks of pregnancy | |
Secondary | HOMA-IR | HOMA-IR was calculated according to the formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5 with blood samples taken from pregnant women in the third trimester. | between 28 and 40 weeks of pregnancy |
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