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The Effect of n-3 PUFA Plant Oil Intake on Human Metabolism — PUFA  

Hyperlipidemias Clinical Trial

Official title:
The Effect of n-3 PUFA Plant Oil Intake on Human Metabolism:A Randomized Double-Blind Trial

Clinical Trial Summary

The findings of previous experiments suggested that polyunsaturated fatty acids(PUFAs) has been linked to anti-hyperlipidemia, and reducing the risk of cardiovascular disease.This is a randomized double-blind trial, aims to study the effect of PUFAs on blood lipids and human metabolism. Firstly, the investigators will investigate the efficacy of mixed plant oil(echium oil, camelina oil, safflower oil) and pure echium oil on improving the levels of blood lipids. Secondly, next generation sequencing (NGS), ultra-high performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) and gas chromatography-mass spectrometry detection will be conducted to explore the role of PUFAs on gut microbiota as well as metabolites. Thirdly, single nucleotide polymorphism will be genotyped by Time-of-flight mass spectrometry to find the gene-environment interaction effect.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03484988
Study type Interventional
Source Huazhong University of Science and Technology
Contact Liegang Liu, MD,PhD
Phone +86-27-83650522
Email liegangliu@gmail.com
Status Not yet recruiting
Phase N/A
Start date June 2018
Completion date September 2019
View Details
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