Hyperlipidemia Clinical Trial
Official title:
Effect of Fenofibrate and Rosuvastatin on Sexual Dysfunction in Hyperlipidemic Patients. A Randomized Trial
Hyperlipidemias are frequently associated with and are considered an important cause of
erectile dysfunction in men. This association has been attributed to the impairment of blood
flow through endothelium-dependent relaxation in smooth muscle cells of corpus cavernosum.
Basic science and human research suggest that the vascular pathophysiology of male and
female sexual dysfunction may be similar, as the first phase of the female sexual response
is mediated by a combination of vasocongestive and neuro-muscular event which include
increased clitoral length and diameter, as well as increased vaginal lubrication, wall
engorgement and luminal diameter. The investigators have shown that women with
hyperlipidemia had a higher prevalence of sexual dysfunction as compared with age-matched
women without hyperlipidemia.
The aim of this study was to asses the effect of anti-hyperlipidemic drugs (fenofibrate and
rosuvastatin, single or in combination) on validated indices of sexual function in
hyperlipidemic men and women with sexual dysfunction at baseline.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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