Evaluate Low Doses of AEGR-733 on Hepatic Fat Accumulation by MRS

Status Completed

Clinical Trial Summary

To determine safety and effectiveness of low-dose therapeutic AEGR-733 +/- atorvastatin, ezetimibe or fenofibrate (compared to placebo) on liver fat accumulation measured by Magnetic Resonance Spectroscopy

Clinical Trial Description

The goal within the current development program and this study is to investigate whether lower doses of AEGR-733 can result in significant reductions in LDL-C and TGs while providing fewer gastrointestinal adverse events and less hepatic fat accumulation than seen in studies with higher doses. The potential for atorvastatin, ezetimibe or the PPAR-alpha agonist (fenofibrate) to ameliorate any hepatic fat accumulation will also be investigated. The twelve week dosing schedule allows us to demonstrate the longer term effects of lower doses of MTP-I on hepatic fat accumulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00559962
Study type	Interventional
Source	Aegerion Pharmaceuticals, Inc.
Contact
Status	Completed
Phase	Phase 2
Start date	October 2007
Completion date	November 2008

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