Hyperinsulinism Clinical Trial
OBJECTIVES: I. Confirm the inhibitory effect of recombinant human insulin-like growth factor
I (IGF-I) on insulin secretion in children with hyperinsulinism.
II. Define the effects of short term IGF-I therapy on postprandial blood sugar levels in
this patient population.
III. Characterize the effects of short term IGF-I therapy on fasting behavior, and other
insulin dependent parameters, in this patient population.
PROTOCOL OUTLINE: Octreotide and/or diazoxide are discontinued on day 1, and fasting blood
glucose is monitored. Patients receive test meals of Sustacal on days 3 and 4 and are
assessed for insulin response.
Beginning on day 5, patients are given recombinant human insulin-like growth factor I
subcutaneously every 12 hours for a total of 3 doses. The first dose (on day 5) is given 30
minutes before a Sustacal challenge, the second dose is followed by a bedtime snack, and the
third dose (on day 6) is followed by a supervised fast.
;
Primary Purpose: Treatment
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