Effect of Insulin on Endothelin-Dependent Vascular Tone in NCT00001624

Clinical Trial Details — Status: Completed

Administrative data
NCT number	NCT00001624
Other study ID #	970100
Secondary ID	97-H-0100
Status	Completed
Phase	Phase 1
First received	November 3, 1999
Last updated	March 3, 2008
Start date	March 1997
Est. completion date	March 2000

Study information
Verified date	February 1999
Source	National Institutes of Health Clinical Center (CC)
Contact	n/a
Is FDA regulated	No
Health authority	United States: Federal Government
Study type	Interventional

Clinical Trial Summary

Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.

Description:

Recruitment information / eligibility
Status	Completed
Enrollment	16
Est. completion date	March 2000
Est. primary completion date
Accepts healthy volunteers	Accepts Healthy Volunteers
Gender	Both
Age group	N/A and older
Eligibility	Between 40-65 years old. No medications. No medical problems. No serum cholesterol levels below 200 mg/dl. No contraceptives.

Study Design

Endpoint Classification: Safety Study, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Insulin

Locations
Country	Name	City	State
United States	National Heart, Lung and Blood Institute (NHLBI)	Bethesda	Maryland

Sponsors *(1)*
Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States,

References & Publications (2)

Donckier J, Stoleru L, Hayashida W, Van Mechelen H, Selvais P, Galanti L, Clozel JP, Ketelslegers JM, Pouleur H. Role of endogenous endothelin-1 in experimental renal hypertension in dogs. Circulation. 1995 Jul 1;92(1):106-13. — View Citation

Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994 Sep 24;344(8926):852-4. — View Citation

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Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation

Clinical Trial Details — Status: Completed

Administrative data

Study information