Hyperinsulinemia Clinical Trial
Official title:
Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli. ;
Endpoint Classification: Safety Study, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05733455 -
Effect of Alpelisib in Healthy Volunteers
|
Phase 1 | |
| Recruiting |
NCT05126199 -
Time-restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome
|
N/A | |
| Completed |
NCT00409422 -
Effects of a Comprehensive Weight Management Program on Obese Adolescents and Children
|
N/A | |
| Completed |
NCT00005669 -
Metformin to Treat Obesity in Children With Insulin Resistance
|
Phase 2 | |
| Completed |
NCT00005760 -
Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
|
N/A | |
| Recruiting |
NCT06444984 -
The Movie Theater Study
|
N/A | |
| Completed |
NCT01409382 -
Maternal Lifestyle and Neonatal Hypoglycemia
|
N/A | |
| Completed |
NCT00667498 -
Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance
|
Phase 4 | |
| Completed |
NCT02653092 -
Reprometabolic Syndrome Mediates Subfertility in Obesity
|
N/A | |
| Recruiting |
NCT05854251 -
Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β
|
Phase 2 | |
| Completed |
NCT02852759 -
A Cold Physical Treatment to Manage Insulin Resistance
|
N/A | |
| Recruiting |
NCT04309071 -
Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans
|
N/A | |
| Completed |
NCT00618072 -
EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance
|
Phase 2 | |
| Completed |
NCT01125150 -
Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia
|
N/A | |
| Suspended |
NCT03374215 -
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
|
||
| Recruiting |
NCT05724134 -
Pancreatic Clamp in NAFLD
|
Phase 1 | |
| Active, not recruiting |
NCT05135234 -
Developing a Physiological Understanding of High Duration Activity
|
N/A | |
| Recruiting |
NCT05729282 -
Glycemic Effect of Diazoxide in NAFLD
|
Phase 1 | |
| Withdrawn |
NCT02642523 -
Natriuretic Peptides and Metabolic Risk in Obesity
|
Early Phase 1 | |
| Completed |
NCT00015691 -
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities
|
N/A |