Hypercholesterolemia Clinical Trial
Official title:
The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
The study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. Fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses any cognitive decline.
The relationship between total serum cholesterol (TC) levels and cognition remains wily.
Some studies suggested that high TC level in old peoples is associated with a decreased risk
of dementia.
Other studies have indicated that hypercholesterolemia may be a risk factor for cognitive
decline and Alzheimer's disease (AD).
But a recent study published in 2014 by Cheng and colleagues, showed that, an inverse
U-shaped relationship between total cholesterol level and cognitive score was found only in
participants with normal homocysteine levels. Indicating that both low and high total serum
cholesterol were associated with lower cognitive scores, ended to the relationship between
cholesterol levels and cognitive function depends upon homocysteine levels, suggesting an
interactive role between cholesterol and homocysteine on cognitive function in the elderly
peoples.
The effect of high serum homocysteine (HHcy) levels on cognition was overwhelming regardless
of the serum cholesterol levels but in peoples with normal homocysteine levels, both low and
high cholesterol levels may be detrimental to cognitive health.
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