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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05652101
Other study ID # 69HCL22_0568
Secondary ID 2022-A02107-36
Status Recruiting
Phase
First received
Last updated
Start date April 24, 2023
Est. completion date April 1, 2025

Study information

Verified date May 2024
Source Hospices Civils de Lyon
Contact Laurence LION FRANCOIS, MD,PhD
Phone 04 27 85 53 77
Email laurence.lion-francois@chu-lyon.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Hereditary hyperekplexia is a rare neuronal disorder, caused by genetic defects leading to dysfunction of glycinergic neurotransmission. The clinical presentation is characterized by stiffness and exaggerated startle responses to unexpected stimuli, that appear shortly after birth. The generalised stiffness can lead to apnea and sudden infant death syndrome. Several genes are known to be associated with hereditary hyperekplexia. The most frequent are Glycine Receptor Alpha 1 (GLRA1), Glycine Receptor Beta (GLRB) and Solute Carrier Family 6 Member 5 (SLC6A5). They encode for the postsynaptic glycine receptor (GLRA1, GLRB) and the presynaptic glycine transport (SLC6A5). Genetic mutations in these genes lead to dysfunction in the glycinergic inhibitory neurotransmission. The neurodevelopment was initially described as normal, or as delayed due to the motor difficulties. Global development delay and intellectual disability are reported as well, in the most recent studies. Nevertheless, the degree of severity of the learning difficulties and the adaptive faculties of the patients is not specified. Similarly, the efficacy of clonazepam in hyperekplexia is well known, but the evolution of dosage over time and the frequency of complete withdrawal have never been studied. The primary endpoint of this study is to describe adaptive skills using a standardized questionnaire, Vineland Adaptive Behavior Scale (VABS2). Secondary endpoints are: - Neurodevelopmental course study - Description of the evolution of the clinical manifestations over the years - Evaluation of the efficacity of the treatment CLONAZEPAM, initially and over time, and evolution of the dosage - Comparison of clinical and therapeutical characteristics according to the genotype


Recruitment information / eligibility

Status Recruiting
Enrollment 40
Est. completion date April 1, 2025
Est. primary completion date April 1, 2025
Accepts healthy volunteers No
Gender All
Age group 2 Years and older
Eligibility Inclusion Criteria: - Clinical diagnostic criteria for hyperekplexia (see Thomas et al. BRAIN, 2013): - The presence of hypertonia (either hypertonia on examination, axial or segmental, or access of stiffness) - Exaggerated reflex startles, to auditory, tactile or visual stimuli - The presence of reflex bursts on percussion of the midline - Children >2 years and adults - No opposition of one of the two parents (or legal representative) or of the adult patient Exclusion Criteria: - The presence of a cause secondary to the hyperekplexia (traumatic, autoimmune, etc.) - The presence of another cause for a delay in psychomotor development (other neurological pathology, serious head trauma, etc.) - Pregnant or breastfeeding women - Person deprived of liberty by judicial or administrative decision

Study Design


Related Conditions & MeSH terms


Intervention

Other:
collection of medical data
The data collected concerns: Sex Age Socio-professional category of patients or parents / level of education of the parents Family history Neonatal patient data (pregnancy, childbirth) Clinical data (age of onset of symptoms, evolution of these symptoms over the years, psychomotor development, schooling, learning difficulties, rehabilitation) Therapeutic data (treatments tried, their dosage and effectiveness, changes in dosage over the years) Paraclinical examinations (Magnetic Resonance Imaging (MRI), scanner, Electroencephalography (EEG)) Genetic data if available
Vineland Adaptive Behaviour Scales (VABS2) questionnaire
This is a standardized semi structured interview that measures adaptative skills in 4 areas, in the fields of communication, socialization, daily living, and motricity (for children under 7 years). It can be used for children and adults. Rating: 2 = yes, usually, 1 = sometimes or partly, 0 = no, never, N = not applicable (when a child is not yet of sufficient age, for example), NS = don't know. The results by domain and by sub-domain are given in raw scores which are then transformed into equivalent ages using a grid provided for this purpose.

Locations

Country Name City State
France Hopital Femme Mère Enfant Bron

Sponsors (1)

Lead Sponsor Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary VABS2 total score and specific scores (socialization, communication, daily living and motricity) The VABS2 measures adaptative scores in the fields of :
Communication (receptive, expressive, written)
Daily Living Skills (personal, domestic and in community)
Socialisation (interpersonal relationships, play and leisure time, coping skills)
Motor Skills (gross and fine motor) for children under 7 years.
The domains are made up of subdomains in which the scores are added to form the domain composite scores. The four domain composite scores then combine to form the adaptive behaviour composite for those individuals aged birth to 6 years 11 months. Three domain composite scores (communication, daily living skills and socialization) combine to form the adaptive behaviour composite for those aged 7 through 90.
The results are expressed with standard scores, percentile ranks, adaptive levels and age equivalents.
maximum 2 months after the inclusion
See also
  Status Clinical Trial Phase
Terminated NCT01476514 - Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain Processing N/A
Completed NCT05168969 - Hyperekplexia in Patients With CTNNB1 Mutation