Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas — GRADIENT

Hypercortisolism Clinical Trial

Official title:
Glucocorticoid Receptor Antagonism in the Treatment of Hypercortisolism in Patients With Cortisol-Secreting Adrenal Adenomas or Hyperplasia: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Relacorilant

Status Recruiting

Clinical Trial Summary

This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with diabetes mellitus/ impaired glucose tolerance and/or uncontrolled systolic hypertension.

Clinical Trial Description

This Phase 3 study patients will be randomized in a 1:1 ratio to treatment with relacorilant (active drug) or placebo. Patients will receive relacorilant or placebo for 22 weeks. Patients who complete the study may also be eligible to roll over into an extension study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04308590
Study type	Interventional
Source	Corcept Therapeutics
Contact	Clinical Trial Lead
Phone	650 327 3270
Email	GRADIENTstudy@corcept.com
Status	Recruiting
Phase	Phase 3
Start date	July 27, 2020
Completion date	March 29, 2024

View Details

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