Hypercholesterolemia Clinical Trial
Official title:
Lipid-lowering Regimes Improve Oxidative Stress, Tryptophan Degradation in Hypercholesterolemia Chronic Kidney Disease Patients
This study aims to determine the mechanisms underlying dyslipidemia in chronic kidney disease (CKD) and effect of lipid-lowering therapies in patients with CKD via parameters of lipid, oxidative stress, tryptophan delegation as well as renal function and side effects. Thirty 3,4 CKD patients with low-density lipoprotein (LDL) > 100 mg/mL (2,59mmol/l), randomly receive three different LDL lipid-lowering therapies: Simvastatin (40 mg/day) or ezetimibe/simvastatin combination (10/20 mg/day or 10/40 mg/day).
The prevalence of chronic kidney disease (CKD) in Vietnamese population is increasing along
with hypertension and diabetes. In CKD patient, cardiovascular disease (CVD) is the leading
cause of mortality. The lipidemic disorder is one of the CV risk factors in CKD but it was
not fully concerned in Viet Nam.
Hypocholesterolemia therapy has shown many benefits; however, its effects on OS and
endothelial function are still not fully evidenced.
In clinical practice, physicians always concern the effects and safety before giving the
prescription. However, despite the high frequency of statin treatment, only 1/3 of CKD
patients achieved the LDL-C goal. Whether high-dose of statins mono-therapy is more effective
in LDL-C lowering is still unclear, but are associated with a high rate of hepatotoxicity,
myopathy.
Lowering LDL-C with statin mono-therapy and statin/ezetimibe combination reduces the risk of
CVD in population without kidney disease. Which Cholesterol-lowering therapies are suitable
for stage 3,4 CKD patients in term of e-GFR reduction and side effects? There is no data
related to this field in the Vietnamese CKD population.
Thus, more advanced lipid-lowering therapies and a better understanding of the mechanism is
needed for treatment strategy of hyperlipidemia in Vietnamese patients with CKD.
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