Hypercholesterolemia Clinical Trial
Official title:
A Randomized Study of the Relative Bioavailability, Pharmacodynamics, Safety of SAR236553 (REGN727) After Single Subcutaneous Administration at 3 Different Injection Sites in Healthy Subjects
Primary Objective:
To assess the relative bioavailability of a single subcutaneous dose of alirocumab SAR236553
(REGN727) administered at 3 different injection sites in healthy subjects.
Secondary Objectives:
- To assess the pharmacodynamic effect of a single subcutaneous dose of alirocumab
SAR236553 (REGN727) on serum low-density lipoprotein cholesterol and other lipids and
apolipoproteins.
- To assess the safety of a single subcutaneous dose of alirocumab SAR236553 (REGN727).
- To assess the immunogenicity of a single subcutaneous dose of alirocumab SAR236553
(REGN727).
Total duration of the study per subject is about 15 weeks. ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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