Hypercholesterolemia Clinical Trial
Official title:
A Randomized, Partial Blind, 3 Parallel Groups Study of the Pharmacodynamic Profile of SAR236553 (REGN727) Administered as Multiple Subcutaneous Doses, Either Alone or on Top of Ezetimibe or Fenofibrate Administered as Multiple Oral Doses in Healthy Subjects
Primary Objective:
To assess the pharmacodynamic profile of alirocumab (SAR236553/REGN727) administered either
alone or on top of ezetimibe or fenofibrate, based on low-density lipoprotein -cholesterol
(LDL-C).
Secondary Objectives:
- To assess the pharmacodynamic profile of alirocumab administered either alone or on top
of ezetimibe or fenofibrate, based on other lipid parameters.
- To assess the pharmacokinetic profile of alirocumab administered either alone or on top
of ezetimibe or fenofibrate.
Total duration of the study per subject (excluding screening) is about 22 weeks. ;
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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