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NCT00546559 Clinical Trial

Differential Metabolic Effects of Statins

Hypercholesterolemia Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00546559
Other study ID # GMC-200406
Secondary ID
Status Completed
Phase N/A
First received October 18, 2007
Last updated August 28, 2008
Start date January 2004
Est. completion date March 2008

Study information
Verified date August 2008
Source Gachon University Gil Medical Center
Contact n/a
Is FDA regulated No
Health authority South Korea: Institutional Review Board
Study type Observational

Clinical Trial Summary

The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date March 2008
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 25 Years to 75 Years
Eligibility Inclusion Criteria:

- Low-density lipoprotein cholesterol levels > 130

Exclusion Criteria:

- Overt liver disease,

- Chronic renal failure

- Hypothyroidism

- Myopathy

- Uncontrolled diabetes

- Severe hypertension

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Drug:
• statins (simvastatin, pravastatin)

Locations
Country Name City State
Korea, Republic of Gil Medical Center Incheon

Sponsors (1)
Lead Sponsor Collaborator
Gachon University Gil Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):120 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
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