Hypercapnia Clinical Trial
Official title:
Influence of Graded Hypercapnia on Endurance Exercise Performance
Verified date | May 2022 |
Source | United States Army Research Institute of Environmental Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this randomized, single-blind, placebo-controlled crossover trial is to determine the effects of graded hypercapnia (0, 2, and 4% inspired CO2) on endurance performance. Twelve healthy and fit young adults (men and women) will complete this study. Participants will perform experimental trials on 3 separate days (one each breathing 0%, 2%, and 4% inspired CO2-all with normal 21% oxygen). During each trial, they will perform 10 minutes of submaximal treadmill walking exercise and then complete a self-paced 2-mile treadmill run time-trial.
Status | Completed |
Enrollment | 15 |
Est. completion date | April 14, 2022 |
Est. primary completion date | April 14, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Male or female, age 18-45 - In good health as determined by medical screening - Passed his/her most recent Army Combat Fitness Test (ACFT) (Military Volunteers Only) or performs aerobic exercise at least 2 times per week and able to complete two mile run in = 21 minutes (Civilian Volunteers) - Willing to not participate in any exercise or drink alcoholic beverages for 24 hours before each study visit. - Willing to not take part in any strenuous exercise in the 36 hours before each visit. - Willing not to drink caffeine or eat food until after testing on familiarization and performance testing visits (visits 2-6). - Willing to maintain a similar dietary pattern in the 2 days before each familiarization and performance visits. - Have supervisor approval if permanent party military or a federal employee at U.S. Army Natick Soldier System Center - Able to speak and read English fluently Exclusion Criteria: - Females who are pregnant or planning to become pregnant during the study - Taking dietary supplements, prescriptions, or over the counter medication, other than a contraceptive (unless approved by medical staff & PI) - Musculoskeletal injuries that compromise ability to run on a treadmill - Abnormal blood count, presence of abnormal blood chemicals (hemoglobin S or sickle cell traits) - Smokers or tobacco/nicotine users (unless have quit > 1 month prior) - Any history of asthma - Current or recent respiratory tract or sinus infections (< 1 month prior) - Allergy to skin adhesive - Any history of migraine or recurrent headaches - Any history of panic disorder - Blood donation in the previous 8 weeks - Positive Covid-19 test within the last month |
Country | Name | City | State |
---|---|---|---|
United States | USARIEM | Natick | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
United States Army Research Institute of Environmental Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 2 mile self-paced treadmill time trial performance | Time to complete self-paced 2 mile treadmill time trial (min:sec) | 30 minutes | |
Secondary | Ventilation rate | Ventilation rate will be assessed using a pneumotachometer [L/min] | 30 minutes | |
Secondary | Oxygen consumption | Oxygen consumption will be assessed using computerized indirect calorimetry [ml/kg/min] | 30 minutes | |
Secondary | Heart rate | Heart rate will be assessed using telemetry [beats per min] | 30 minutes | |
Secondary | Arterialized capillary pH | Arterialized capillary pH will be assessed using a blood gas analyzer [Unitless] | 30 minutes | |
Secondary | Arterialized capillary pCO2 | Arterialized capillary pCO2 will be assessed using a blood gas analyzer [mmHg] | 30 minutes | |
Secondary | Arterialized capillary HCO3 | Arterialized capillary HCO3 will be assessed using a blood gas analyzer [mEq/L] | 30 minutes | |
Secondary | Rating of perceived exertion | Rating of perceived exertion will be assessed using Borg's 6-20 scale [AU] | 30 minutes | |
Secondary | Dyspnea | Rating of perceived dyspnea will be assessed using Borg's 0-10 scale [AU] | 30 minutes | |
Secondary | Leg discomfort | Rating of perceived leg discomfort will be assessed using Borg's 0-10 scale [AU] | 30 minutes | |
Secondary | Headache | Headache will be assessed using a visual analog scale [AU] | 30 minutes | |
Secondary | Breathing descriptors | Breathing descriptors will be assessed by having participants check statements that apply to their breathing (e.g., breathing out requires more effort) [unitless] | 30 minutes |
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