Clinical Trials Logo

Clinical Trial Summary

The purpose of this research study is to better understand how blood flow and metabolism are different between normal controls and patients with disease. The investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, such as normal brain growth, exercise, or deep concentration. Significant illness or physiologic stress may increase the brain's metabolic demand or cause other bigger changes in blood flow. If blood vessels are not able to expand to give more blood flow when metabolic demand is high, the brain may not get all of the oxygen it needs. In less extreme circumstances, not having as much oxygen as it wants may cause the brain to grow and develop more slowly than it should. One way to test the ability of the blood vessels to expand is by measuring blood flow while breathing in carbon dioxide (CO2). CO2 causes blood vessels in the brain to dilate without increasing brain metabolism. The study team will use a special mask to control the amount of oxygen and carbon dioxide patients breath in so that we can study how their brain reacts to these changes. This device designed to simulate carbon dioxide levels achieved by a breath-hold and target the concentration of carbon dioxide in the blood in breathing patients. The device captures exhaled gas and provides an admixture of fresh gas and neutral/expired gas to target different carbon dioxide levels while maintaining a fixed oxygen level. The study team will obtain MRI images of the brain while the subjects are breathing air controlled by the device.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04258774
Study type Interventional
Source Washington University School of Medicine
Contact
Status Enrolling by invitation
Phase N/A
Start date January 29, 2020
Completion date December 31, 2027

See also
  Status Clinical Trial Phase
Terminated NCT02801162 - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard N/A
Completed NCT02917668 - Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients N/A
Completed NCT02429154 - Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants (VARO) N/A
Not yet recruiting NCT02201875 - Intrinsic Periodic Pattern of Breathing N/A
Completed NCT01898858 - Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic N/A
Completed NCT02068274 - CO2 Monitoring Study N/A
Completed NCT00006318 - Role of Prostaglandins in the Regulation of Brain Blood Flow N/A
Completed NCT00001845 - Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) N/A
Completed NCT05116397 - Influence of Graded Hypercapnia on Endurance Exercise Performance N/A
Completed NCT03221387 - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients N/A
Completed NCT05470465 - Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation Phase 1
Recruiting NCT05505279 - Ventilatory Effects of THRIVE During EBUS Phase 3
Completed NCT04497090 - Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation N/A
Completed NCT01882257 - Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury N/A
Terminated NCT00710541 - Non-invasive Ventilation in Severe Chronic Obstructive Pulmonary Disease(COPD) N/A
Completed NCT05189158 - Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants N/A
Completed NCT04409470 - Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients
Completed NCT04512781 - Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs N/A
Recruiting NCT03741998 - Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange N/A
Recruiting NCT05761756 - Oxygen Toxicity: Mechanisms in Humans N/A