Clinical Trials Logo
  1. Home
  2. Hypercapnia
  3. NCT02429154

Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants (VARO) — VARO  

Hypercapnia Clinical Trial

Official title:
Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants

Clinical Trial Summary

The purpose of this study is to show that a permissive hypercapnia during mechanical ventilation in children under general anaesthesia will improve cerebral perfusion.

Clinical Trial Description

Mechanical ventilation interferes with cerebral perfusion via the changes in intrathoracic pressure and/or as a consequence of hypocapnia. This latter occurs frequently following traditional ventilation strategies with relatively high tidal volume and respiratory rate. New trends in anesthesia intend to promote protective lung ventilation by keeping a normocapnic or even mildly hypercapnic state. However, cerebral vascular vasotonicity is carbon dioxide (CO2)-dependent with hypocapnia potentially leading to vasoconstriction and subsequent decrease in cerebral blood flow. Changes in cerebral vasoreactivity can be assessed by the near infrared spectroscopy (NIRS) device. This monitoring evaluates the changes in various parameters (deoxygenated hemoglobin, oxygenated hemoglobin, the tissue oxygenation index (TOI) and the tissue hemoglobin index (THI)) that act as surrogate for cerebral vasoconstriction.

We, therefore designed this prospective observational comparative effectiveness study in order to characterize the potential beneficial effect of permissive hypercapnia on cerebral perfusion in infants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02429154
Study type Interventional
Source University Hospital, Geneva
Contact
Status Completed
Phase N/A
Start date September 2015
Completion date September 30, 2017
View Details
See also
  Status Clinical Trial Phase
Completed NCT02917668 - Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients N/A
Terminated NCT02801162 - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard N/A
Not yet recruiting NCT02201875 - Intrinsic Periodic Pattern of Breathing N/A
Completed NCT01898858 - Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic N/A
Completed NCT02068274 - CO2 Monitoring Study N/A
Completed NCT00006318 - Role of Prostaglandins in the Regulation of Brain Blood Flow N/A
Completed NCT00001845 - Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) N/A
Completed NCT05116397 - Influence of Graded Hypercapnia on Endurance Exercise Performance N/A
Completed NCT03221387 - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients N/A
Completed NCT05470465 - Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation Phase 1
Recruiting NCT05505279 - Ventilatory Effects of THRIVE During EBUS Phase 3
Completed NCT04497090 - Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation N/A
Completed NCT01882257 - Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury N/A
Terminated NCT00710541 - Non-invasive Ventilation in Severe Chronic Obstructive Pulmonary Disease(COPD) N/A
Completed NCT05189158 - Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants N/A
Completed NCT04409470 - Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients
Completed NCT04512781 - Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs N/A
Recruiting NCT03741998 - Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange N/A
Recruiting NCT05761756 - Oxygen Toxicity: Mechanisms in Humans N/A
Recruiting NCT02980770 - Postoperative Complications in Patients With Obesity Hypoventilation Syndrome N/A