Hypercapnia Clinical Trial
Official title:
Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants
The purpose of this study is to show that a permissive hypercapnia during mechanical ventilation in children under general anaesthesia will improve cerebral perfusion.
Mechanical ventilation interferes with cerebral perfusion via the changes in intrathoracic
pressure and/or as a consequence of hypocapnia. This latter occurs frequently following
traditional ventilation strategies with relatively high tidal volume and respiratory rate.
New trends in anesthesia intend to promote protective lung ventilation by keeping a
normocapnic or even mildly hypercapnic state. However, cerebral vascular vasotonicity is
carbon dioxide (CO2)-dependent with hypocapnia potentially leading to vasoconstriction and
subsequent decrease in cerebral blood flow. Changes in cerebral vasoreactivity can be
assessed by the near infrared spectroscopy (NIRS) device. This monitoring evaluates the
changes in various parameters (deoxygenated hemoglobin, oxygenated hemoglobin, the tissue
oxygenation index (TOI) and the tissue hemoglobin index (THI)) that act as surrogate for
cerebral vasoconstriction.
We, therefore designed this prospective observational comparative effectiveness study in
order to characterize the potential beneficial effect of permissive hypercapnia on cerebral
perfusion in infants.
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