Hypercapnia Clinical Trial
— H2PAPOfficial title:
Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic
The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during
a short constant load exercise in 4 conditions :
- normoxia
- hypoxia
- hypercapnia
- association hypoxia and hypercapnia
Status | Completed |
Enrollment | 8 |
Est. completion date | October 2014 |
Est. primary completion date | October 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion criteria: - healthy male - exercise capacity between 100 and 130 % of theorical values Exclusion criteria: - smoker - headache - impossibility to perform an exercise test - no tricuspid regurgitation on the echocardiography |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | Service de Physiologie et d'Explorations Fonctionnelles, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg | Strasbourg |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Strasbourg, France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Systolic Artery Pulmonary Pressure(sPAP) (echocardiography, Cardiac output (impedancemetry), Cardiorespiratory parameters | At rest and during exercise for each condition | at the end of the 30th minutes constant load exercise | No |
Secondary | Dyspnea and muscle leg discomfort using a Borg Scale | In each conditions at rest and during exercise | at the end of the 30th minutes constant load exercise | No |
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