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Antecubital Versus Femoral Approach for Adrenal Venous Sampling — AFAVS  

Hyperaldosteronism Clinical Trial

Official title:
Antecubital Versus Femoral Approach for Adrenal Venous Sampling: A Randomised Controlled Trial

Clinical Trial Summary

Subtype diagnosis is crucial for the treatment of primary aldosteronism (PA), which conducts the appropriate treatment strategy. Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. At present, almost all medical centers use the femoral vein approach for AVS, and most studies report that the success rate is 30%-80%. Our research team is the first in the world to conduct AVS via an antecubital approach. The aim of this study is to compare the success rate and safety of AVS via antecubital and femoral approach.

Clinical Trial Description

Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, and its most common subtypes are aldosterone-producing adenoma and idiopathic hyperaldosteronism, which account for 95% to 98% of PA. Subtype diagnosis is crucial for the treatment of primary aldosteronism, which conducts the appropriate treatment strategy. Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. At present, almost all medical centers use the femoral vein approach for AVS, and most studies report that the success rate is 30%-80%.How to improve the success rate of AVS has been a hot topic in the field of primary aldosteronism. Our research team is the first in the world to conduct AVS via an antecubital approach. The previous study found that the success rate of AVS via this approach can reach to 88.0%, with a low incidence of complications. In this study, patients with primary aldosteronism who meet the indications of AVS will be randomly assigned to antecubital approach group and femoral approach group. Clinical, laboratory and examination data will be recorded and the success rate and safety of AVS via antecubital and femoral approach will be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06029803
Study type Interventional
Source Chinese Academy of Medical Sciences, Fuwai Hospital
Contact Hui Dong, MD
Phone 86-010-88322387
Email donghui666@sina.com
Status Recruiting
Phase N/A
Start date April 1, 2022
Completion date November 30, 2023
View Details
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