Huntington's Disease Clinical Trial
Official title:
A Multi-Center, Double-Blind, Randomized, Parallel Group Tolerability Study of Coenzyme Q10 (UbiquinonE)in PRE-manifest Huntington's Disease
To establish the tolerability of treatment with 600, 1200 or 2400 mg per day of coenzyme Q10 in pre-manifest participants carrying the CAGn expansion for Huntington's Disease (HD).
secondary objectives:
1. To assess the change from baseline to 20 weeks on biomarkers of oxidative stress (8OHdG
and 8OHrG) and DNA repair mechanisms (OGG1) in pre-manifest participants treated with
600, 1200 or 2400 mg per day of CoQ10.
2. To assess the dose-response relationship between CoQ10 at dosages of 600, 1200 or 2400
mg per day and 8OHdG/8OHrG and OGG1.
3. To assess the serum levels of CoQ10 at 600, 1200 or 2400 mg in pre-manifest participants
and their relationship to 8OHdG/8OHrG and OGG1.
4. To assess the feasibility of implementing a preventive therapeutic trial in a
pre-manifest population.
5. To assess the utility and stability of clinical measures of HD, social relations,
behavior and employment in a pre-manifest sample enrolled in a treatment trial.
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|---|---|---|---|
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